陆德婵
一、个人简介
陆德婵，1994年出生，讲师，硕士生导师；入选福建省C类人才、beat365英国官方网站青年拔尖人才；主持国家自然科学青年基金、福建省自然科学基金、福建省中青年教师教育科研项目科技类重点项目、beat365英国官方网站人才引进启动基金项目、医工交叉项目等项目；目前以第一作者发表SCI论文15篇，授权发明专利4件，研究方向是智能SERS传感与人工智能光谱识别技术。
教育经历：
2020.9-2023.7 福建师范大学，光学工程，博士（导师：黄祖芳）
2017.9-2020.7 福建师范大学，应用化学，硕士（导师：卢玉栋）
2013.9-2017.7 福州大学至诚学院，材料化学，学士
工作经历：
2023.7-至今 beat365英国官方网站 智能制造学院 生物医学工程系 讲师
邮箱：DechanLu@163.com
二、科研项目
研究项目
1.“基于cfDNA甲基化SERS光谱技术的肺结节良恶性评估”，国家自然科学青年基金，2026.1-2028.12，主持，30万
2.“基于无亚硫酸氢盐处理的血浆cfDNA甲基化SERS分析及在肺结节良恶性诊断研究”福建省自然科学基金，2025.9-2028.8，主持，8万
3.“基于SERS光谱技术的肺癌早期诊断的分子标志物的筛选”，beat365英国官方网站人才引进启动基金，2024.1-2026.12, 主持，30万。
4. “基于多受体传感器的肺癌外泌体识别技术”，福建省中青年教师教育科研项目科技类重点项目, 2024.1-2026.12，主持，5万。
5. “基于DNA甲基化SERS检测的肺癌早期筛查诊断研究”， beat365英国官方网站交叉学科专项医科/工科，2024.7-2027.6，主持，5万。
三、科研成果
论文著作
1.Lu Dechan, Zhou Xiaoqi, Su Dandan, Li Jundong, Lin Huizhen ,Qiu Rongmao pH-assisted ratiometric surface-enhanced Raman scattering for reliable creatinine cquantification in serum. Colloids and Surfaces B: Biointerfaces 261(2026)115454.(SCI 收录)
2.Lin Huizhen, Chen Jiawang, Chen Yiming, Lu Dechan* ,SERS-based deep learning approach for early detection of gestational diabetes mellitus Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 351 (2026) 127472. (SCI 收录)
3.Lu Dechan, Su Dandan, Yang Yi, et al. Hydrophobic substrate integrated SERS technology for rapid detection of uric acid [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 345: 126781.(SCI 收录)
4. Lu Dechan, Lin Jinwen, Su Dandan, et al. Recent progress in SERS technology applications in lung cancer Detection: From biomarkers to samples [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 343: 126481.(SCI 收录)
5.Lu Dechan, Chen Yanping, Ke Longfeng, et al. Bisulfite-free detection of DNA methylation in early-stage lung cancer with a multiplex SERS immunoassay [J]. Chemical Engineering Journal, 2024, 503: 158491.(SCI 收录)
6.Lu Dechan, Huang Zufang, Chen Jingbo, et al. pH-Adjusted Liquid SERS Approach: Toward a Reliable Plasma-Based Early Stage Lung Cancer Detection [J]. Analytical Chemistry, 2024, 9(1): 508–15.(SCI 收录)
7.Lu Dechan, Shangguan Zhikun, Su Zhehao, et al. Artificial intelligence-based plasma exosome label-free SERS profiling strategy for early lung cancer detection [J]. Analytical and Bioanalytical Chemistry, 2024, 416(23): 5089-96.(SCI 收录)
8.Lu Dechan., Zhang Bohan., Shangguan Zhikun., Lu Yudong., Chen Jingbo., Huang Zufang., Machine learning-based exosome profiling of multi-receptor SERS sensors for differentiating adenocarcinoma in situ from early-stage invasive adenocarcinoma.Colloids Surf B Biointerfaces. 2024;236: 113824。
9.Lu Dechan., Chen Yanping., Ke Longfeng., Wu Weilin., Yuan Liwen., Feng Shangyuan., Huang Zufang., Lu Yudong., Wang Jing. Machine learning-assisted global DNA methylation fingerprint analysis for differentiating early-stage lung cancer from benign lung diseases. Biosens Bioelectron. 2023;235: 115235.2.
10.Lu Dechan., Chen Cairou., Xu Peipei., You Ruiyun., Lu Zhenzhen., Lu Yudong. Two-dimensional substrate assisted SERS immunosensor for accurate detection of carcinoembryonic antigen. Spectrochim Acta A Mol Biomol Spectrosc. 2023;302: 123142.3.
11.Lu Dechan, Cai Rongyuan, Liao Yuqin, You Ruiyun, Lu Yudong. Two-dimensional glass/p-ATP/Ag NPs as multifunctional SERS substrates for label-free quantification of uric acid in sweat. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2023;296: 122631.4.
12.Lu Dechan., Zhang Qun., Huang Zufang., Lu Yudong., Feng Shangyuan., You Ruiyun., Li Minling., Zhang Shaoqin. Ratiometric SERS quantitative analysis of tyrosinase activity based on gold-gold hybrid nanoparticles with Prussian blue as an internal standard. Colloids Surf B Biointerfaces. 2022;217: 112645.
13.Lu Dechan., Lin Xueliang., Chen Cairou., Lu Yudong., Feng Shangyuan., Huang Zufnag., You Ruiyun., Chen Jingbo., Wu Yang. Interference-free SERS tags for ultrasensitive quantitative detection of tyrosinase in human serum based on magnetic bead separation. Anal Chim Acta. 2020;1138: 150-157.6.
14.Lu Dechan., Fan Min., Cai Rongyuan., Huang Zufang., You Ruiyun., Huang Luqiang., Feng Shangyuan., Lu Yudong. Silver nanocube coupling with a nanoporous silver film for dual-molecule recognition based ultrasensitive SERS detection of dopamine. Analyst. 2020;145: 3009-3016.7.
15.Lu Dechan#., Zhang Bohan., You Ruiyun, Chen Jingbo., Machine learning-assisted internal standard calibration label-free SERS strategy for colon cancer detection. Anal Bioanal Chem. 2023;415: 1699-1707.8.
16.Gao Feng#, Lu Dechan#, Zheng Tianlei, Geng Shi, Sha Juncheng, Huang Ouyang, Tang Liangjie, Zhu Peiwu, Li Yangyang, Chen Lili, Targher Giovanni, Byrne Christopher D., Huang Zufang, Zheng Minghua, consortium Chess-Mafld. Fully connected neural network-based serum surface-enhanced Raman spectroscopy accurately identifies non-alcoholic steatohepatitis. Hepatology International. 2022.
专利：
1.陆德婵；翁婷炜；卢玉栋；黄祖芳；朱兰瑾；一种基于AuPB@Au NPs荧光检测酪氨酸酶的方法，2020-03-17，中国，ZL2020101878521（专利）
2.陆德婵；陈彩柔；卢玉栋；黄祖芳；刘显鹏；沈慧英；一种用于检测酪氨酸酶活性的SERS基底及利用该基底检测酪氨酸酶活性的方法，2020-02-17，中国，ZL2020100966671（专利）
3.陆德婵; 许慧瑶; 卢玉栋; 沈慧英; 吴阳; 陈玉婷; 一种双分子识别多巴胺表面增强拉曼传感 器的制备及应用，2019-01-11，中国，ZL2018112229363（专利）
4.陆德婵；先丽；卢玉栋；翁婷炜；沈慧英；吴阳；朱兰瑾；陈玉婷；一种用于检测酪氨酸酶的三明治结构SERS传感器及其制备和检测方法，2019-04-25，中国，ZL2019103372155（专利）
四、其他
个人荣誉
2024年获福建省C类人才称号
2024年或beat365英国官方网站青年拔尖人才称号
