杜丽阳，1995年出生，讲师，中级，硕士生导师；入选莆田市四类人才；医学微生态学福建省高校重点实验室秘书；主持省部级科研项目1项，市厅级科研项目1项，校级科研项目1项；以第一作者在Nucleic Acids Research，EMBO Journal等期刊发表多篇SCI论文。
研究方向
1、光敏剂抗菌药物的合成及应用等相关领域研究
2、细菌关键调控蛋白的分子机制及靶标药物发现
研究项目
1. 太阳光高效捕获型BODIPY光敏剂构建及其防治柑橘溃疡病的光动力抑菌机制研究，福建省科技厅项目，2026.05-2029.4，10万元，主持
2. 阳离子型氟硼二吡咯光敏剂的合成及细菌性创口感染愈合机制研究，福建省教育厅项目，2026.01-2028.12，1万元，主持
3. III型CRISPR-Cas系统中环寡腺苷酸信号通路的分子机制研究，beat365英国官方网站科研项目，2024.07-2027.06，20万元，主持
论文著作
1. De-Chao Yang, Huamei Zhuang, Jiayi Zheng, Liyang Du*, Jianmin Chen*, Jian-Yong Liu*. Hypoxia-responsive nano-photosensitizer anchored by PEGylated BODIPY: a single-laser-driven platform for photo-enhanced synergistic chemo/photodynamic/photothermal cancer therapy, Molecular Pharmaceutics, 2025, 22, 5603−5615.
2. Liyang Du, Danping Zhang, Zhipu Luo*, Zhonghui Lin*. Molecular basis of stepwise cyclic tetra-adenylate cleavage by the Type III CRISPR ring nuclease Crn1/Sso2081, Nucleic Acids Research, 2023, 51, 2485-2495.
3. Liyang Du, Qinwei Zhu, Zhonghui Lin*. Molecular mechanism of allosteric activation of the CRISPR ribonuclease Csm6 by cyclic tetra-adenylate, EMBO Journal, 2024, 43, 304-315. （第一作者）
4. Qinwei Zhu#, Liyang Du#, Juhong Wu#, Jinyu Li*, Zhonghui Lin*. Walrycin B, as a novel separase inhibitor, exerts potent anticancer efficacy in a mouse xenograft model, Biochemical Pharmacology, 2024, 229, 116502.
5. Danping Zhang, Liyang Du, Haishan Gao, Cai Yuan*, Zhonghui Lin*. Structural insight into the Csx1-Crn2 fusion self-limiting ribonuclease of type III CRISPR system, Nucleic Acids Research, 2024, 52, 8419-8430.
6. De chao Yang, Linfeng Wen, Liyang Du, Chenmiao Luo, Ziyao Lu, Jianyong Liu*, Zhonghui Lin*. A hypoxia-activated prodrug conjugated with a BODIPY-based photothermal agent for imaging-guided chemo-photothermal combination therapy. ACS Applied Materials & Interfaces. 2022, 14, 40546-40558.
7. Yuhua He, Wei Fu, Liyang Du, Huiqiao Yao, Zhengkang Hua, Jinyu Li, Zhonghui Lin*. Discovery of a novel Aurora B inhibitor GSK650394 with potent anticancer and anti-aspergillus fumigatus dual efficacies in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022 Dec;37(1):109-117.
知识产权
1. 林忠辉、杜丽阳、朱钦未. 一种分离酶抑制剂在抗肿瘤方面的应用. 202311224610.5. 2025.11. （发明专利，授权）
联系方式
邮箱：duliyang1995@163.com
